According to People magazine, the 29-year-old married writer Lauren Miller on Saturday, in the town of Sonoma, California.
The ceremony took place near a vineyard. Jonah Hill, Adam Sandler and Paul Rudd were among guests.
Rogen, 29, and Miller, 30, met in 2004 and got engaged last year in September.
“Seth is so excited,” a source said at the time of their engagement. “Lauren is such a sweet girl. She makes him really happy.”