Dina Eastwood, 48, filed divorce papers on Tuesday citing irreconcilable differences.
The former E! reality star asked for custody of their daughter Morgan, 16, as well as spousal support and attorney fees.
Dina Eastwood filed a legal separation, on October 7, which she withdrew shortly afterwards, before submitting the complete file for divorce this week.
Clint Eastwood and Dina Ruiz married in 1996.