On Friday night Spears set fire at Planet Hollywood Resort & Casino in the famous world capital of gambling.
For 90 minutes, the singer, 32, performed a selection of more than 20 of her hit songs, including Everytime, Toxic, Lucky, Baby One More Time or Womanizer, summarizing her fifteen-year career.
Several celebrities made the trip to Las Vegas for the show, including pop stars Miley Cyrus, Selena Gomez and Katy Perry.
At the end of the show, Britney shared her enthusiasm on Twitter.
“Wow … Perfect audience for the first show of the Piece of Me! It was extraordinary! Vegas, I love you!” she tweeted.
During her two-year residency in Las Vegas, Britney will perform nearly a hundred times on stage.