Theron is set to play the role of a doctor who participates in a humanitarian action in Africa, and who faces the violence generated by a political conflict in the region.
Her character will meet another doctor, played by Spanish actor Javier Bardem, who is there for the same reason. He is placed in a position where he has to choose between his love and dedication to his work.
The cast will also include French actress Adele Exarchopoulos in the role of a journalist.
The movie will reportedly be shot in Africa this summer.