Milano, who is already mom to son Milo Thomas, born in 2011, announced the happy news on her website on Thursday.
“I’m in my Mistresses dressing room and I wanted to share with you guys that I am expecting a little sweet baby girl,” she said. “David, Milo and I could not be happier. Truly, we could not be happier. So exciting!”
The actress, 41, shared a selfie on her Instagram account in April with her baby bump, adding a short caption, “the bump,” with the hashtags “#shortpeoplecarrybig #noitsnottwins.”
Alyssa Milano and her husband David Bugliari were married in 2009.