The comedian, 40, took to Twitter on Wednesday to respond to those speculations.
“Um…there have been a lot of men who’ve touched my boobies, but not one of them has ever been a doctor,” she tweeted.
This was followed by another tweet and a picture proving that she is all-natural.
“Here idiots. A totally sober portrayal of proof,” she wrote on Wednesday next to the photo.
Handler’s response comes after Us Weekly reported this month that the former E! host had a “breast lift” just before her 40th birthday.