According to a source cited by Page Six, Barrymore, 41, and Kopelman, 38, who began dating in 2011 and tied the knot in 2012, are planning to get divorced.
Reps for the couple, who are parents to daughters, Olive, 3, and Frankie, 1, haven’t made any comment so far.
The last time Barrymore shared a photo on Instagram of her husband was last June when they celebrated their three-year anniversary.
“Happy anniversary Mr. Kopelman, cheers to you! I love you and I love our daughters !!!!!!! #threeyears,” the Charlie’s Angels actress wrote.
Recently, Barrymore tattooed her daughters’ names on her right wrist.
“Getting a great little lifetime note on my arm,” the actress captioned one of the photos.
The E.T. the Extra-Terrestrial actress was previously married to bar owner Jeremy Thomas in 1994 and comedian Tom Green in 2001.