The American actor and the French singer have been together in the past 14 years.
For several months, the press has continued to write about the deteriorating relationship of one of the most glamorous and strong Hollywood couples.
The couple “have amicably separated,” Depp’s publicist said in a statement to Entertainment Tonight Tuesday and added: “Please respect their privacy and, more importantly, the privacy of their children.”
Johnny and Vanessa were last seen together in public at the Cannes Film Festival in May 2010.
The beginning of the relationship between Johnny Depp, 49, and Vanessa Paradis, 39, dates back to 1998. Depp and Paradis, who are not married, have two children, Lily-Rose, 13, and Jack, 9.
The family lived in the small village of Plan-de-la-Tour in the south of France, away from the Hollywood paparazzi.